Injury, repair and degeneration

Traumatic damage to the brain and spinal cord constitutes some of the most devastating central nervous system disorders. Residents in the Department of Anatomy and Neurobiology are a nationally recognized team of investigators focused on the study, treatment and repair of CNS damage. The group uses contemporary cellular, molecular and electrophysiological approaches to study initiating pathogenesis, therapeutic targeting to attenuate damage and delayed interventions to expedite the recovery and repair. Faculty members in the department have extensive collaborative ties with basic and clinical scientists in other academic units who are involved in similar lines of research.

Severn Ben Churn, Ph.D.
Cellular mechanisms of neurotrauma and epilepsy

Raymond J. Colello, Ph.D.
Oligodendrocyte migration and myelination; biology of neural stem/progenitor cells; neurogenesis following traumatic brain injury

Richard M. Costanzo, Ph.D. 
Neural regeneration, repair and replacement in the mammalian nervous system; mechanisms of neurogenesis and neuronal recovery following injury

Kimberle M. Jacobs, Ph.D.
Functional, electrophysiological effects of traumatic brain injury and potential treatments

Audrey Lafrenaye, Ph.D. 
Exploring the diffuse neuronal and glial pathologies precipitated by traumatic brain injury and how secondary elevations in intracranial pressure alter the progression of these pathologies

A. Rory McQuiston, Ph.D. 
Pathophysiology and susceptibility of specific synapses, neurons and neural networks to pathogenic tau formation in models of Alzheimer’s disease

Gretchen N. Neigh, Ph.D.
Impact of stress on outcome from CNS injury

Andrew K. Ottens, Ph.D. 
Mechanisms underlying neurobiological outcomes from inhaling pollutants and man-made airborne materials in the environment. Molecular diagnostics and therapeutic targeting of post-translational processes following traumatic brain injury

Linda L. Phillips, Ph.D.
Interaction between excessive neuro-excitation and neuronal deafferentation following traumatic brain injury and how this interaction affects both the ensuing pathology and recovery mechanisms involving synaptic plasticity

John T. Povlishock, Ph.D.
Elucidating the initiating mechanisms that lead to brain damage following traumatic brain injury, focusing on both traumatically induced vascular and axonal changes

Thomas M. Reeves, Ph.D. 
Structural, molecular, and functional correlates of traumatic brain injury focusing on injury-induced changes in neurons affecting information processing

Dong Sun, M.D., Ph.D.
Biology of neural stem and progenitor cells; neurogenesis; neural transplantation; traumatic brain injury

Patricia A. Trimmer, Ph.D. 
The role that mitochondrial impairment plays in the neurodegeneration that characterizes Alzheimer’s and Parkinson’s diseases